Early menopause can be a risk factor for development Alzheimersbut the women who have taken to hormone therapy around the age of onset did not show an increased risk of developing the disease, according to a study published today by JAMA Neurology.
A team of Mass General Brigham of the United States studied the relationship between Alzheimer’s disease risk and menopausal age and use of hormone therapy (HT).
Findings indicate that younger age in menopause may be a risk factor for Alzheimer’s dementia, but that women prescribed hormone therapy around the age of onset They did not show an increased risk.
“HT is the most reliable way to relieve severe menopausal symptoms, but how HT affects the brain hasn’t been understood in recent decades,” explained the study author. Rachel Buckleyof Massachusetts General Hospital, USA.
The team found that higher levels of tau, a protein involved in Alzheimer’sthey were observed only in hormone therapy users who reported a long delay between the age of onset of menopause and the start of therapy.
Early menopause is one that occurs spontaneously. before age 40 or due to surgery before the age of 45.
Hormone therapy improves many severe menopause-related symptoms, and it has been speculated that it may as well prevents cognitive decline.
The study analyzed how the presence of two proteins implicated in Alzheimer’samyloid-beta and tau, with age at menopause and HT consumption.
Previous studies suggest that starting HT early in menopause, rather than late, provides better outcomes for heart diseasecognitive function and all-cause mortality, and this study “suggests that the same is true for tau deposition,” said the author. JoAnn Manson.
Hormone therapy can have negative effects on cognition, but only if it begins several years after the age of menopause. These observational findings support clinical guidelines that hormone therapy should be given near the onset of menopause but not several years later, the researchers noted.
“When it comes to hormone therapy, the timing is everything”added Manson. EFE
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